Methyl iodide → HCID 13548776, compound

HRID 2419664Notes

Reaction equation

HRID 2419664 reaction equation
[CH3:1][C:2]1[N:3]=[CH:4][N:5]2[C:10]=1[CH:9]=[N:8][NH:7][C:6]2=[S:11].[Na].[CH3:13]I>CO>[CH3:1][C:2]1[N:3]=[CH:4][N:5]2[C:10]=1[CH:9]=[N:8][N:7]=[C:6]2[S:11][CH3:13]

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 5360545SodiumHCID 13548750HCID 13548750, compound

Product 1

HCID 13548776HCID 13548776, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A 1.66 gm. portion of 8-methyl-imidazo[1,5-d]-as-triazine-4(3H)-thione is added to a solution of 0.23 gm. of sodium in 10 ml. of methanol. A 0.75 ml. portion of methyl iodide is added, the mixture is allowed to stand for 30 minutes and then evaporated to dryness. The product is chromatographed on a silica gel column. The appropriate fractions are recrystallized from acetone giving the desired product, m.p. 128°-129° C.

Workup

  1. customevaporated to dryness
  2. customThe product is chromatographed on a silica gel column
  3. customThe appropriate fractions are recrystallized from acetone giving the desired product, m.p. 128°-129° C.

Sources & evidence

ORD record
ord-3984c2e3277b4e4da592c684d9e46491
Source dataset
uspto-grants-1978_08
Patent number
US04107308

Reaction notes

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