Methyl iodide → HCID 13548777, compound

HRID 2419681Notes

Reaction equation

HRID 2419681 reaction equation
[CH3:1][O:2][CH2:3][C:4]1[N:8]2[C:9](=[S:13])[NH:10][N:11]=[CH:12][C:7]2=[CH:6][N:5]=1.[H-].[Na+].I[CH3:17]>CN(C)C=O>[CH3:1][O:2][CH2:3][C:4]1[N:8]2[C:9]([S:13][CH3:17])=[N:10][N:11]=[CH:12][C:7]2=[CH:6][N:5]=1

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 12493300HCID 12493300, compound

Product 1

HCID 13548777HCID 13548777, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A slurry of 0.98 gm of 6-(methoxymethyl)-imidazo[1,5-d]-as-triazine-4(3H)-thione in 10 ml of N,N-dimethylformamide is treated with 0.28 gm of 50% sodium hydride in oil. Gentle warming is applied until the effervescence stops and then 0.41 ml of iodomethane is added. The resulting precipitate is collected, washed with ether, recrystallized from acetone then ethanol, to yield the above-noted desired product having a melting point equal to 179°-181° C.

Workup

  1. temperatureGentle warming
  2. customThe resulting precipitate is collected
  3. washwashed with ether
  4. customrecrystallized from acetone

Sources & evidence

ORD record
ord-a8938a2d491649bf86075ad5bd29fd3c
Source dataset
uspto-grants-1978_08
Patent number
US04107308

Reaction notes

Loading…