反应详情

温度

150 °C

To 4-chloro-6-(6-methoxypyridin-3-yl)-1-methyl-1H-pyrazolo[3,4-b]pyridine (0.32 g) and 4-(methylsulfonyl)phenol (0.40 g) in DMF (6 mL) was added potassium carbonate (0.80 g) and nitrogen was bubbled through the solution for 5 min. The reaction mixture was then heated in a microwave reactor at 150° C. for 1 h. The resulting product was purified by silica gel chromatography (0-30% EtOAc in hexane) to afford 117 (0.38 g). MS (ESI) m/z 411.1 (M+1)+

1. customwas bubbled through the solution for 5 min
2. customThe resulting product was purified by silica gel chromatography (0-30% EtOAc in hexane)