反应详情

A solution of 6 ml. of hydrazine hydrate and the solution of 1,3-dibenzyl-2-methylthiopseudourea hydroiodide from Example 13 in 500 ml. of absolute ethanol is heated at reflux for 4 hours and then evaporated to dryness under reduced pressure. The residual solid is crystallized from isopropyl alcohol twice giving the desired product as colorless crystals, m.p. 135°-137° C.

1. temperatureat reflux for 4 hours
2. customevaporated to dryness under reduced pressure
3. customThe residual solid is crystallized from isopropyl alcohol