Hydrochloric Acid → HCID 178479723, compound

HRID 2419801Notes

Reaction equation

HRID 2419801 reaction equation
[ClH:1].[NH:2]1[CH:6]=[CH:5][N:4]=[C:3]1[NH:7][C:8]([C:10]1[CH:11]=[N:12][C:13]2[C:18]([C:19]=1[OH:20])=[CH:17][CH:16]=[CH:15][C:14]=2[C:21]([F:24])([F:23])[F:22])=[O:9]>O>[ClH:1].[NH:2]1[CH:6]=[CH:5][N:4]=[C:3]1[NH:7][C:8]([C:10]1[CH:11]=[N:12][C:13]2[C:18]([C:19]=1[OH:20])=[CH:17][CH:16]=[CH:15][C:14]=2[C:21]([F:24])([F:22])[F:23])=[O:9]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178522545HCID 178522545, compound

Product 1

HCID 178479723HCID 178479723, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

10 ml of N hydrochloric acid were added to a suspension of 3.2 g of the product of Step A in 250 ml of water and the mixture was heated to 40°-50° C and filtered to remove insolubles. The aqueous filtrate was concentrated to 30 ml and was vacuum filtered. The recovered precipitate was washed with water and dried to obtain the dihydrate of N-(1H-imidazol-2-yl)-4-hydroxy-8-trifluoromethyl-quinoline-3-carboxamide hydrochloride.

Workup

  1. temperaturethe mixture was heated to 40°-50° C
  2. filtrationfiltered
  3. customto remove insolubles
  4. concentrationThe aqueous filtrate was concentrated to 30 ml
  5. filtrationfiltered
  6. washThe recovered precipitate was washed with water
  7. customdried

Sources & evidence

ORD record
ord-4816277efd674ea5a635a84da08f81d7
Source dataset
uspto-grants-1978_08
Patent number
US04107310

Reaction notes

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