Hydrogen Peroxide → HCID 20314614, compound

HRID 2419848Notes

Reaction equation

HRID 2419848 reaction equation
[ClH:1].[F:2][C:3]1[CH:8]=[CH:7][C:6]([S:9][CH2:10][CH2:11][CH2:12][C:13]([NH2:15])=[NH:14])=[CH:5][CH:4]=1.[OH:16]O>C(O)(=O)C>[ClH:1].[F:2][C:3]1[CH:8]=[CH:7][C:6]([S:9]([CH2:10][CH2:11][CH2:12][C:13]([NH2:15])=[NH:14])=[O:16])=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 784Hydrogen PeroxideHCID 20314608HCID 20314608, compound

Product 1

HCID 20314614HCID 20314614, compoundYield 76%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

15 g (0.06 mol) of 4-(p-fluorophenylthio)-butyramidine hydrochloride dissolved in 50 ml of acetic acid are oxidised with 5.6 ml of hydrogen peroxide of 120 volumes strength in 1 hour at 50° C.The mixture is left to stand overnight and is then evaporated in vacuo and the residue is taken up in acetone, filtered off and recrystallised from isopropanol. CRL 40,267 is obtained in a yield of 76%; it is in the form of small white crystals. Melting point = 138° C.

Workup

  1. waitThe mixture is left
  2. customis then evaporated in vacuo
  3. filtrationfiltered off
  4. customrecrystallised from isopropanol
  5. customCRL 40,267 is obtained in a yield of 76%

Sources & evidence

ORD record
ord-da9219d75e16430197acd489b547be6c
Source dataset
uspto-grants-1978_08
Patent number
US04107438

Reaction notes

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