2-(1-Methylethylidene)cyclohexanone → HCID 12220944, compound

HRID 2419980Notes

Reaction equation

HRID 2419980 reaction equation
[Cl:1]([O-:5])(=[O:4])(=[O:3])=[O:2].[CH:6]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[CH2:9][CH2:8][NH+:7]=1.[C:16](=[C:19]1[CH2:24][CH2:23][CH2:22][CH2:21][C:20]1=O)([CH3:18])[CH3:17]>CN(C)C=O.C(O)C>[Cl:1]([O-:5])(=[O:4])(=[O:3])=[O:2].[CH3:18][C:16]1[C:19]2[CH2:24][CH2:23][CH2:22][CH2:21][C:20]=2[N+:7]2[CH2:8][CH2:9][C:10]3[CH:11]=[CH:12][CH:13]=[CH:14][C:15]=3[C:6]=2[CH:17]=1

Participants

5

Reactant 2

HCID 262522-(1-Methylethylidene)cyclohexanoneHCID 20312280HCID 20312280, compound

Product 1

HCID 12220944HCID 12220944, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 6228DimethylformamideSolvent

Procedure

3,4-Dihydroisoquinolinium perchlorate (4.6 g) and 2-isopropylidenecyclohexanone (3 g) were dissolved in dimethylforamide (12 ml) and refluxed for 12 hours. The reaction mixture was cooled, diluted with ethanol, and filtered. The product was purified by recrystallization from methanol. Yield 3 g; m.p. 205°.

Workup

  1. temperaturerefluxed for 12 hours
  2. temperatureThe reaction mixture was cooled
  3. filtrationfiltered
  4. customThe product was purified by recrystallization from methanol

Sources & evidence

ORD record
ord-27135de797264b0ea899086a2a137f3e
Source dataset
uspto-grants-1978_08
Patent number
US04108667

Reaction notes

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