1-Butanol → HCID 86735955, compound

HRID 2420039Notes

Reaction equation

HRID 2420039 reaction equation
[Cl-:1].[CH2:2]([O:4][C:5](=[O:13])[NH:6][CH2:7][CH2:8][CH2:9][NH+:10]([CH3:12])[CH3:11])[CH3:3].Cl.[CH2:15](O)[CH2:16]CC>>[Cl-:1].[CH2:2]([O:4][C:5](=[O:13])[NH:6][CH2:7][CH2:8][CH2:9][NH+:10]([CH3:11])[CH3:12])[CH2:3][CH2:15][CH3:16]

Participants

4

Reactant 3

HCID 2631-ButanolHCID 313Hydrochloric AcidHCID 86735956HCID 86735956, compound

Product 1

HCID 86735955HCID 86735955, compound

Procedure

21.0 g (0.1 mole) of N-(3-dimethylammoniopropyl)-carbamic acid ethyl ester chloride are suspended in 100 ml of n-butanol. Dry HCl gas is introduced into the suspension for a short time and the mixture is heated for 6 hours at 100° to 115° C while stirring, the hydrochloride going into solution and some ml of liquid distilling off. Then concentrate and drag the residue in vacuum. One obtains 18.0 g of nD20 = 1.4750.

Workup

  1. temperaturethe mixture is heated for 6 hours at 100° to 115° C
  2. distillationthe hydrochloride going into solution and some ml of liquid distilling off
  3. concentrationThen concentrate
  4. customOne obtains 18.0 g of nD20 = 1.4750

Sources & evidence

ORD record
ord-dbe8b6cc6bbf4ebf90ad1f9e6ed80a59
Source dataset
uspto-grants-1978_08
Patent number
US04108885

Reaction notes

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