HCID 12917368, compound → HCID 12917376, compound

HRID 2420162Notes

Reaction equation

HRID 2420162 reaction equation
[H-].[Al+3].[Li+].[H-].[H-].[H-].[CH2:7]([N:14]1[C:19](=O)[CH2:18][O:17][CH:16]([CH2:21][O:22][C:23]2[CH:24]=[CH:25][CH:26]=[C:27]3[C:31]=2[CH2:30][CH:29]=[CH:28]3)[CH2:15]1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>O1CCCC1>[CH2:7]([N:14]1[CH2:19][CH2:18][O:17][CH:16]([CH2:21][O:22][C:23]2[CH:24]=[CH:25][CH:26]=[C:27]3[C:31]=2[CH2:30][CH:29]=[CH:28]3)[CH2:15]1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Participants

4

Reactant 2

HCID 12917368HCID 12917368, compoundHCID 21226445Aluminium lithium hydride

Product 1

HCID 12917376HCID 12917376, compoundYield 89%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

In 300 ml. of anhydrous tetrahydrofuran was suspended 20 g. of lithium aluminum hydride and after adding slowly to the suspension a solution prepared by dissolving 8.0 g. of 4-benzyl-2-(7-indenyloxymethyl)morpholin-5-one in 50 ml. of tetrahydrofuran, the mixture was treated in a similar manner as in Example 1 to provide 6.8 g. (yield 89%) of oily 4-benzyl-2-(7-indenyloxymethyl)morpholine.

Workup

  1. customprepared
  2. dissolutionby dissolving 8.0 g
  3. customto provide 6.8 g

Sources & evidence

ORD record
ord-2a2e1a00680c48818b49a9b754ac103e
Source dataset
uspto-grants-1978_08
Patent number
US04109088

Reaction notes

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