HCID 20313216, compound → HCID 20313226, compound

HRID 2420163Notes

Reaction equation

HRID 2420163 reaction equation
[H-].[Al+3].[Li+].[H-].[H-].[H-].[CH2:7]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][C:14]=2[O:16][CH2:17][CH:18]2[O:23][CH2:22][C:21](=O)[N:20]([CH2:25][CH2:26][CH3:27])[CH2:19]2)[CH:9]=[CH:8]1>O1CCCC1>[CH2:7]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][C:14]=2[O:16][CH2:17][CH:18]2[O:23][CH2:22][CH2:21][N:20]([CH2:25][CH2:26][CH3:27])[CH2:19]2)[CH:9]=[CH:8]1

Participants

4

Reactant 2

HCID 20313216HCID 20313216, compoundHCID 21226445Aluminium lithium hydride

Product 1

HCID 20313226HCID 20313226, compoundYield 89.5%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

In 50 ml. of anhydrous tetrahydrofuran was suspended 0.5 g. of lithium aluminum hydride and after adding slowly to the suspension a solution prepared by dissolving 2.0 g. of 2-(7-indenyloxymethyl)-4-propylmorpholin-5-one in 10 ml. of anhydrous tetrahydrofuran, the mixture was treated in a similar manner as in Example 1 to provide 1.7 g. (yield 89.5%) of oily 2-(7-indenyloxymethyl)-4-propylmorpholine.

Workup

  1. customprepared
  2. dissolutionby dissolving 2.0 g
  3. customto provide 1.7 g

Sources & evidence

ORD record
ord-9cc6b6151f654d9ab4d4c4616c70191d
Source dataset
uspto-grants-1978_08
Patent number
US04109088

Reaction notes

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