HCID 20311325, compound → HCID 20311326, compound

HRID 2420227Notes

Reaction equation

HRID 2420227 reaction equation
[CH3:1][C:2]([NH:7][C:8]1[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][C:9]=1[N+:15]([O-])=O)([CH3:6])[C:3]([OH:5])=[O:4]>O1CCCC1.[Ni]>[CH3:6][C:2]([NH:7][C:8]1[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][C:9]=1[NH2:15])([CH3:1])[C:3]([OH:5])=[O:4]

Participants

4

Reactant 1

HCID 20311325HCID 20311325, compound

Product 1

HCID 20311326HCID 20311326, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 8028TetrahydrofuranSolvent

Procedure

48 g (mol/5.36) of 2-methyl-(4'-chloro-2'-nitroanilino)-propionic acid, in 480 ml of tetrahydrofuran, are hydrogenated in the presence of 10 g of Raney nickel in a one-liter autoclave. H2 pressure when cold: 135 kg. Pressure drop (calculated 24.5 kg - actual 30 kg). Temperature: 70°-90° C. Duration: 21/2 hours.

Workup

  1. custom70°-90° C
  2. custom2 hours

Sources & evidence

ORD record
ord-134846102b754ef6aeb65916e10fad4d
Source dataset
uspto-grants-1978_08
Patent number
US04110337

Reaction notes

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