HCID 10515403, compound → HCID 20311330, compound

HRID 2420228Notes

Reaction equation

HRID 2420228 reaction equation
[CH3:1][C:2]([NH:7][C:8]1[CH:13]=[C:12]([Cl:14])[CH:11]=[CH:10][C:9]=1[N+:15]([O-])=O)([CH3:6])[C:3]([OH:5])=[O:4].[H][H]>O1CCCC1.[Ni]>[CH3:6][C:2]([NH:7][C:8]1[CH:13]=[C:12]([Cl:14])[CH:11]=[CH:10][C:9]=1[NH2:15])([CH3:1])[C:3]([OH:5])=[O:4]

Participants

5

Reactant 2

HCID 10515403HCID 10515403, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 20311330HCID 20311330, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 8028TetrahydrofuranSolvent

Procedure

Using a one-liter autoclave, 53.4 g (0.206 mol) of 2-methyl-(5'-chloro-2'-nitroanilino)-propionic acid in solution in 500 ml of tetrahydrofuran are hydrogenated in the presence of 17 g of Raney nickel. Hydrogen pressure in the cold: 120 kg. Temperature 60° C. Duration: 1 hour. Pressure drop:

Workup

  1. customTemperature 60° C

Sources & evidence

ORD record
ord-103544b0d8ae471b9a7ffe7a96f10c5b
Source dataset
uspto-grants-1978_08
Patent number
US04110337

Reaction notes

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