HCID 20311331, compound → HCID 20311328, compound

HRID 2420232Notes

Reaction equation

HRID 2420232 reaction equation
[CH3:1][C:2]([NH:7][C:8]1[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[CH:10][C:9]=1[N+:16]([O-])=O)([CH3:6])[C:3]([OH:5])=[O:4].[H][H]>O1CCCC1.[Ni]>[CH3:6][C:2]([NH:7][C:8]1[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[CH:10][C:9]=1[NH2:16])([CH3:1])[C:3]([OH:5])=[O:4]

Participants

5

Reactant 2

HCID 20311331HCID 20311331, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 20311328HCID 20311328, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 8028TetrahydrofuranSolvent

Procedure

32.6 g (mol/7.8) of 2-methyl-(2'-nitro-4'-methoxyanilino)-propionic acid, in solution in 330 ml of tetrahydrofuran, are hydrogenated in the presence of 20 g of Raney nickel in an autoclave with a capacity of 500 ml. Hydrogen pressure in the cold: 150 kg/cm2. Temperature = 70°-90° C.; Duration: 3 hours

Workup

  1. customTemperature = 70°-90° C.

Sources & evidence

ORD record
ord-e955d19f2e6e4404983f7dcfc27f158a
Source dataset
uspto-grants-1978_08
Patent number
US04110337

Reaction notes

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