Hydrochloric Acid → HCID 67215364, compound

HRID 2420756Notes

Reaction equation

HRID 2420756 reaction equation
C(OC(=O)[NH:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][C:19](=[O:26])[NH:20][C:21]1[NH:22][CH:23]=[CH:24][N:25]=1)(C)(C)C.[ClH:28].O1CCOCC1>>[ClH:28].[ClH:28].[NH:22]1[CH:23]=[CH:24][N:25]=[C:21]1[NH:20][C:19](=[O:26])[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][NH2:7]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 67215655HCID 67215655, compound

Product 1

HCID 67215364HCID 67215364, compound

Procedure

[11-(1H-Imidazol-2-ylcarbarmoyl)undecyl]carbamic acid tert-butyl ester (13) (0.060 g, 0.16 mmol) was treated with 4 M HCl in dioxane (2 mL, 8 mmol) and the mixture stirred at room temperature for 14 hours. The reaction mixture was concentrated in vacuo and further dried under high vacuum. The resulting white solid (0.056 g, 99%) was used directly without further purification. m/z (ESI) 281 [C15H28N4O+H]+.

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. customfurther dried under high vacuum
  3. customThe resulting white solid (0.056 g, 99%) was used directly without further purification

Sources & evidence

ORD record
ord-fc14204a5b3b4b43b882213cd0c25542
Source dataset
uspto-grants-2011_06
Patent number
US07956059B2

Reaction notes

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