反应详情

1-[1-(4-chlorophenyl)cyclopropyl]-3,4-dihydroisoquinolin-7-ol (120 mg, 0.4 mmol) was added in several portions to a suspension of sodium hydrid (NaH, 1.3 mmol, activated by removal of oil) in dimethylformamide (DMF, 5 ml). 2-(Boc-amino)ethyl bromide was added after one hour and the resulting mixture stirred for 3 days at room temperature. DMF was evaporated, the residue diluted with ethylacetate and extracted with water. Removal of the solvents from the dried (Na2SO4) extract afforded an oil which was further purified by chromatography. Yield: 100 mg (0.23 mmol, 56%)

1. customDMF was evaporated
2. additionthe residue diluted with ethylacetate
3. extractionextracted with water
4. customRemoval of the solvents from the
5. dry with materialdried (Na2SO4)
6. extractionextract
7. customafforded an oil which
8. customwas further purified by chromatography