Hydrochloric Acid → HCID 178524962, compound

HRID 2421032Notes

Reaction equation

HRID 2421032 reaction equation
[F:1][C:2]([F:14])([F:13])[C:3]1[NH:7][N:6]=[N:5][C:4]=1[C:8]([O:10]CC)=[O:9].[OH-].[Na+].Cl>>[F:14][C:2]([F:1])([F:13])[C:3]1[NH:7][N:6]=[N:5][C:4]=1[C:8]([OH:10])=[O:9]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 178470511HCID 178470511, compound

Product 1

HCID 178524962HCID 178524962, compoundYield 83.7%

Procedure

Ethyl 5-(trifluoromethyl)-1H-1,2,3-triazole-4-carboxylate (0.312 g) was stirred in aqueous N sodium hydroxide (3.8 mL) and heated under reflux for 90 min. The cooled solution was acidified with aqueous hydrochloric acid and extracted with ethyl acetate. The extracts were washed with brine then dried and evaporated to leave a colourless solid (0.226 g).

Workup

  1. temperatureheated
  2. temperatureunder reflux for 90 min
  3. extractionextracted with ethyl acetate
  4. washThe extracts were washed with brine
  5. customthen dried
  6. customevaporated

Sources & evidence

ORD record
ord-7c704846f6924702bc17e785b104b44d
Source dataset
uspto-grants-2011_06
Patent number
US07956070B2

Reaction notes

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