Sodium Hydroxide → HCID 178482485, compound

HRID 2421036Notes

Reaction equation

HRID 2421036 reaction equation
[CH3:1][N:2]([S:12]([CH3:15])(=[O:14])=[O:13])[C:3]1[NH:7][N:6]=[N:5][C:4]=1[C:8]([O:10]C)=[O:9].[OH-].[Na+]>C1COCC1>[CH3:1][N:2]([S:12]([CH3:15])(=[O:14])=[O:13])[C:3]1[NH:7][N:6]=[N:5][C:4]=1[C:8]([OH:10])=[O:9]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 178499189HCID 178499189, compound

Product 1

HCID 178482485HCID 178482485, compoundYield 20.7%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Methyl 5-[methyl(methylsulfonyl)amino]-1H-1,2,3-triazole-4-carboxylate (0.36 g) was stirred in THF (5 mL) with 2 N aqueous sodium hydroxide solution (1.7 mL) for 18 h. The mixture was concentrated in vacuo. To the aqueous residue was added dilute acetic acid and this was extracted with ethyl acetate (2×15 mL). The extracts were washed with water and brine then dried and evaporated to leave the subtitle compound (0.07 g).

Workup

  1. concentrationThe mixture was concentrated in vacuo
  2. additionTo the aqueous residue was added dilute acetic acid
  3. extractionthis was extracted with ethyl acetate (2×15 mL)
  4. washThe extracts were washed with water and brine
  5. customthen dried
  6. customevaporated

Sources & evidence

ORD record
ord-b1b284016a2e4dea8c7a0118382d2bcb
Source dataset
uspto-grants-2011_06
Patent number
US07956070B2

Reaction notes

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