Lithium Hydroxide → HCID 67215054, compound

HRID 2421039Notes

Reaction equation

HRID 2421039 reaction equation
[Cl:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8]C)=[O:7])=[CH:4][C:3]=1[C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13].[OH-].[Li+]>C1COCC1.O>[C:15]([O:14][C:12]([C:3]1[CH:4]=[C:5]([CH:10]=[CH:11][C:2]=1[Cl:1])[C:6]([OH:8])=[O:7])=[O:13])([CH3:18])([CH3:16])[CH3:17]

Participants

5

Reactant 2

HCID 3939Lithium HydroxideHCID 67215392HCID 67215392, compound

Product 1

HCID 67215054HCID 67215054, compoundYield 91.2%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

3-tert-Butyl 1-methyl 4-chloroisophthalate (0.37 g) in THF (5 mL) was treated with lithium hydroxide (0.17 g) in water (5 mL) and the mixture was stirred for 18 h. The solvent was evaporated. Water and ethyl acetate were added. The aqueous extract was separated and acidified with dilute hydrochloric acid. The product was extracted into ethyl acetate. The solution was dried over sodium sulphate, filtered and the solvent was evaporated to yield the subtitle compound as a white solid (0.32 g).

Workup

  1. customThe solvent was evaporated
  2. additionWater and ethyl acetate were added
  3. extractionThe aqueous extract
  4. customwas separated
  5. extractionThe product was extracted into ethyl acetate
  6. dry with materialThe solution was dried over sodium sulphate
  7. filtrationfiltered
  8. customthe solvent was evaporated

Sources & evidence

ORD record
ord-acf4d6197e4f4ea0b1ea723921341a7e
Source dataset
uspto-grants-2011_06
Patent number
US07956070B2

Reaction notes

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