Hydrochloric Acid → HCID 59025450, compound

HRID 2421074Notes

Reaction equation

HRID 2421074 reaction equation
[CH2:1]([N:4]1[C@H:8]2[CH2:9][CH2:10][CH2:11][CH2:12][C@@H:7]2[N:6]([CH:13]2[CH2:18][CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15][CH2:14]2)[C:5]1=[O:26])[CH:2]=[CH2:3].Cl>CO>[CH2:1]([N:4]1[C@H:8]2[CH2:9][CH2:10][CH2:11][CH2:12][C@@H:7]2[N:6]([CH:13]2[CH2:14][CH2:15][NH:16][CH2:17][CH2:18]2)[C:5]1=[O:26])[CH:2]=[CH2:3]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 59025429HCID 59025429, compound

Product 1

HCID 59025450HCID 59025450, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Tert-butyl 4-[(3aS,7aS)-3-allyl-2-oxooctahydro-1H-benzimidazol-1-yl]piperidine-1-carboxylate was dissolved in methanol (20 mL) and 4 M HCl (7 mL) was then added. The mixture was stirred at room temperature and then concentrated in vacuo. The salt was then converted to freebase by using MP-carbonate. MS (M+1): 264.2.

Workup

  1. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-8350971c4e724581bb7bfb6b42a30eab
Source dataset
uspto-grants-2011_06
Patent number
US07956069B2

Reaction notes

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