Hydrochloric Acid → HCID 59025434, compound

HRID 2421085Notes

Reaction equation

HRID 2421085 reaction equation
[O:1]=[C:2]1[CH2:10][C@@H:9]2[C@H:4]([CH2:5][CH2:6][CH2:7][CH2:8]2)[N:3]1[CH:11]1[CH2:16][CH2:15][N:14]([CH:17]2[CH2:22][CH2:21][N:20](C(OC(C)(C)C)=O)[CH2:19][CH2:18]2)[CH2:13][CH2:12]1.Cl>CO>[N:14]1([CH:17]2[CH2:18][CH2:19][NH:20][CH2:21][CH2:22]2)[CH2:13][CH2:12][CH:11]([N:3]2[C@@H:4]3[C@H:9]([CH2:8][CH2:7][CH2:6][CH2:5]3)[CH2:10][C:2]2=[O:1])[CH2:16][CH2:15]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 59025447HCID 59025447, compound

Product 1

HCID 59025434HCID 59025434, compoundYield 89.3%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of tert-butyl 4-[(3aR,7aS)-2-oxooctahydro-1H-indol-1-yl]-1,4′-bipiperidine-1′-carboxylate (180 mg, 0.44 mmol) in MeOH (3 mL) was added 4M HCl (1 mL) and the mixture was stirred at room temperature. The solvents were then removed under reduced pressure to provide the title compound as yellow oil (120 mg). Ms (M+1): 306.3

Workup

  1. customThe solvents were then removed under reduced pressure

Sources & evidence

ORD record
ord-cfd543b4b5ca478bad2970573288d5fa
Source dataset
uspto-grants-2011_06
Patent number
US07956069B2

Reaction notes

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