Ethyl Acetate → HCID 178510886, compound

HRID 2421269Notes

Reaction equation

HRID 2421269 reaction equation
[C:1]1([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH:6]=[CH:5][C:4]([C:7]2[N:8]=[C:9]([CH2:12][CH2:13][NH:14]C(=O)OC(C)(C)C)[NH:10][CH:11]=2)=[CH:3][CH:2]=1.C(OCC)(=O)C>Cl>[C:1]1([C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=2)[CH:6]=[CH:5][C:4]([C:7]2[N:8]=[C:9]([CH2:12][CH2:13][NH2:14])[NH:10][CH:11]=2)=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 8857Ethyl AcetateHCID 178453345HCID 178453345, compound

Product 1

HCID 178510886HCID 178510886, compoundYield 89%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

tert-butyl 2-(4-[1,1′-biphenyl]-4-yl-1H-imidazol-2-yl)ethylcarbamate (4.8 g; 0.013 mol) is stirred in 120 ml of a solution of ethyl acetate saturated in hydrochloric acid for 2 hours 30 minutes at a temperature of 55° C. The solid obtained is filtered and washed with ether. A light beige-coloured powder is obtained with a yield of 89%.

Workup

  1. customThe solid obtained
  2. filtrationis filtered
  3. washwashed with ether
  4. customA light beige-coloured powder is obtained with a yield of 89%

Sources & evidence

ORD record
ord-2af9fce93fef4700a6f614d6295f1a6b
Source dataset
uspto-grants-2011_06
Patent number
US07956075B2

Reaction notes

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