Water → HCID 21914306, compound

HRID 2421314Notes

Reaction equation

HRID 2421314 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([Br:8])=[CH:4][N:3]=1.[CH2:9]([S:11]([N:14]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1)(=[O:13])=[O:12])[CH3:10].C(N(C(C)C)CC)(C)C.O>CC(N(C)C)=O>[Br:8][C:5]1[CH:6]=[CH:7][C:2]([N:17]2[CH2:16][CH2:15][N:14]([S:11]([CH2:9][CH3:10])(=[O:12])=[O:13])[CH2:19][CH2:18]2)=[N:3][CH:4]=1

Participants

6

Reactant 4

HCID 962WaterHCID 693532,5-DibromopyridineHCID 81531DiisopropylethylamineHCID 4152941-(Ethanesulfonyl)piperazine

Product 1

HCID 21914306HCID 21914306, compound

Reagents, catalysts & solvents 1

HCID 31374DimethylacetamideSolvent

Procedure

2,5-Dibromopyridine (1 g) was heated in dimethylacetamide (2.5 ml) with ethanesulfonylpiperazine (0.752 g) and diisopropylethylamine (1.84 ml) at 120° C. for 18 h. After cooling, the reaction mixture was poured into water (30 ml) and the precipitated solid was collected by filtration. The product was purified by column chromatography eluting with dichloromethane (0.50 g).

Workup

  1. temperatureAfter cooling
  2. filtrationthe precipitated solid was collected by filtration
  3. customThe product was purified by column chromatography
  4. washeluting with dichloromethane (0.50 g)

Sources & evidence

ORD record
ord-95a7faec448041e5a923810dd267e93e
Source dataset
uspto-grants-2011_06
Patent number
US07956084B2

Reaction notes

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