Potassium Carbonate → HCID 21914345, compound

HRID 2421376Notes

Reaction equation

HRID 2421376 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9](=[O:11])[CH3:10])=[CH:4][C:3]=1[OH:12].C(=O)([O-])[O-].[K+].[K+].Cl.Cl[CH2:21][CH2:22][N:23]1[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]1>CC(C)=O>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9](=[O:11])[CH3:10])=[CH:4][C:3]=1[O:12][CH2:21][CH2:22][N:23]1[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 74826Piperidine, 1-(2-chloroethyl)-, hydrochlorideHCID 21914379HCID 21914379, compound

Product 1

HCID 21914345HCID 21914345, compoundYield 60.7%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

N-(4-Bromo-3-hydroxyphenyl)acetamide (19.4 g), anhydrous potassium carbonate (25.6 g), 1-(2 chloroethyl)piperidine hydrochloride (15.78 g) and acetone (400 ml) were heated at reflux for 18 h, filtered and evaporated to dryness to give the product as a solid (17.48 g).

Workup

  1. temperatureat reflux for 18 h
  2. filtrationfiltered
  3. customevaporated to dryness

Sources & evidence

ORD record
ord-09888266b3b7463b8465dde2fbec876d
Source dataset
uspto-grants-2011_06
Patent number
US07956084B2

Reaction notes

Loading…