Potassium Iodide → HCID 21914295, compound

HRID 2421391Notes

Reaction equation

HRID 2421391 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[O:8][CH2:9][CH2:10]Cl.Cl.[F:13][CH:14]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1.C(=O)([O-])[O-].[K+].[K+].[I-].[K+]>CN(C)C=O>[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[O:8][CH2:9][CH2:10][N:17]1[CH2:18][CH2:19][CH:14]([F:13])[CH2:15][CH2:16]1

Participants

6

Reactant 4

HCID 4875Potassium IodideHCID 11430Potassium CarbonateHCID 27591584-Fluoropiperidine hydrochlorideHCID 27790271-bromo-2-(2-chloroethoxy)benzene

Product 1

HCID 21914295HCID 21914295, compoundYield 33.2%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
80 °C

Procedure

A mixture of 1-bromo-2-(2-chloroethoxy)benzene (2.35 g), 4-fluoropiperidine hydrochloride (1.54 g), potassium carbonate (4.06 g) and potassium iodide (0.83 g) in dimethylformamide (20 ml) was heated at 80° C. for 18 h. After evaporation, the residue was partitioned between ethyl acetate and water. The solvent phase was washed (brine), dried and evaporated to give an oil (1.0 g).

Workup

  1. customAfter evaporation
  2. customthe residue was partitioned between ethyl acetate and water
  3. washThe solvent phase was washed (brine)
  4. customdried
  5. customevaporated

Sources & evidence

ORD record
ord-0b689be964124d368ef1c9a5ad536f67
Source dataset
uspto-grants-2011_06
Patent number
US07956084B2

Reaction notes

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