Hydrochloric Acid → 3-Bromo-8-iodo-quinolin-6-ylamine

HRID 2421534Notes

Reaction equation

HRID 2421534 reaction equation
[Br:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([CH:11]=1)=[CH:9][C:8]([N+:12]([O-])=O)=[CH:7][C:6]=2[I:15].Cl>[Fe]>[Br:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([CH:11]=1)=[CH:9][C:8]([NH2:12])=[CH:7][C:6]=2[I:15]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 672145383-Bromo-8-iodo-6-nitro-quinoline

Product 1

HCID 672147063-Bromo-8-iodo-quinolin-6-ylamine

Reagents, catalysts & solvents 1

HCID 23925IronCatalyst

Procedure

In a similar procedure to Stage 1, Step 1 of Example 6, 3-bromo-8-iodo-6-nitro-quinoline was treated with concentrated hydrochloric acid and iron powder to give 3-bromo-8-iodo-quinolin-6-ylamine as a beige powder ((M+1)+ 351).

Sources & evidence

ORD record
ord-5d785e3a9d7c462b99a098b611e27805
Source dataset
uspto-grants-2011_06
Patent number
US07956188B2

Reaction notes

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