Hydrochloric Acid → HCID 23588190, 화합물

HRID 2421642노트

반응식

HRID 2421642 반응식
C[O:2][C:3](=[O:14])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([CH2:10][CH:11]([CH3:13])[CH3:12])[CH:5]=1.[OH-].[Na+].Cl>CCO>[CH2:10]([C:6]1[CH:5]=[C:4]([CH:9]=[CH:8][CH:7]=1)[C:3]([OH:14])=[O:2])[CH:11]([CH3:13])[CH3:12]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 20771995Methyl 3-isobutyl-benzoate

생성물 1

HCID 23588190HCID 23588190, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

94A (1.07 g, 5.5 mmol) was suspended in EtOH (10 mL) and aqueous NaOH (1 M, 20 mL) and was heated to 80° C. for forty-five minutes. Upon cooling to room temperature, the solution was acidified with HCl (conc.), was cooled to 0° C., and was filtered. The white crystalline precipitate was dried under vacuum (262 mg, 27%). NMR 1H (ppm, CDCl3): 7.94-7.89 (m, 2H), 7.39-7.33 (m, 2H), 2.53 (d, J3=7.2 Hz, 2H), 1.94-1.85 (m, 1H), 0.90 (t, J3=6.6 Hz, 6H).

후처리

  1. temperaturewas cooled to 0° C.
  2. filtrationwas filtered
  3. customThe white crystalline precipitate was dried under vacuum (262 mg, 27%)

출처 및 근거

ORD 기록
ord-12fe79e4627d4fca9df182fa2a11dd57
출처 데이터셋
uspto-grants-2011_06
특허 번호
US07956216B2

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