Hydrochloric Acid → HCID 67242897, compound

HRID 2421856Notes

Reaction equation

HRID 2421856 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:26]=[C:27]([F:29])[CH:28]=1)[CH2:5][N:6]1[C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=2[S:10][CH2:9][C@H:8]([NH:17]C(=O)OC(C)(C)C)[C:7]1=[O:25].[ClH:30]>O1CCOCC1>[ClH:30].[NH2:17][C@@H:8]1[C:7](=[O:25])[N:6]([CH2:5][C:4]2[CH:3]=[C:2]([F:1])[CH:28]=[C:27]([F:29])[CH:26]=2)[C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=2[S:10][CH2:9]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57649590HCID 57649590, compound

Product 1

HCID 67242897HCID 67242897, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

1.59 g of 2 (3.78 mmol) are placed in a 100 mL round-bottomed flask and 25 mL of a solution of hydrogen chloride in dioxane (4 M) are added. The medium is stirred for 5 hours at room temperature under argon. After evaporating off the solvent, 1.44 g of amine 3 are obtained in hydrochloride form, which product is used directly for the following step.

Workup

  1. customAfter evaporating off the solvent, 1.44 g of amine 3
  2. customare obtained in hydrochloride form, which product

Sources & evidence

ORD record
ord-46fe8060a4b24d53b25a83d2a33ea55f
Source dataset
uspto-grants-2011_06
Patent number
US07960373B2

Reaction notes

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