Hydrochloric Acid → HCID 67242544, compound

HRID 2421859Notes

Reaction equation

HRID 2421859 reaction equation
[ClH:1].[Br:2][C:3]1[C:13]2[S:12][CH2:11][C@H:10]([NH:14]C(=O)OC(C)(C)C)[C:9](=[O:22])[NH:8][C:7]=2[CH:6]=[CH:5][CH:4]=1>O1CCOCC1>[ClH:1].[NH2:14][C@@H:10]1[C:9](=[O:22])[NH:8][C:7]2[CH:6]=[CH:5][CH:4]=[C:3]([Br:2])[C:13]=2[S:12][CH2:11]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86629173HCID 86629173, compound

Product 1

HCID 67242544HCID 67242544, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

10 mL of a solution of hydrogen chloride in dioxane (4 M) are added to a 25 mL round-bottomed flask containing 500 mg of 20 (1.34 mmol). The mixture is stirred for 4 hours at room temperature under argon. A white precipitate forms, which is filtered off by suction and washed with 3 mL of dioxane and then 5 mL of isopropyl ether. 386 mg of amine 21 (beige-coloured solid) are thus obtained in the form of hydrochloride.

Workup

  1. filtrationA white precipitate forms, which is filtered off by suction
  2. washwashed with 3 mL of dioxane

Sources & evidence

ORD record
ord-63d83e245b9d416daf6af898970abfa9
Source dataset
uspto-grants-2011_06
Patent number
US07960373B2

Reaction notes

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