Hydrochloric Acid → HCID 67242480, compound

HRID 2421862Notes

Reaction equation

HRID 2421862 reaction equation
[ClH:1].CC(C)(C)C(O[NH:7][C@@H:8]1[C:14](=[O:15])[NH:13][C:12]2[CH:16]=[CH:17][CH:18]=[C:19]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[C:11]=2[S:10][CH2:9]1)=O>O1CCOCC1>[ClH:1].[NH2:7][C@@H:8]1[C:14](=[O:15])[NH:13][C:12]2[CH:16]=[CH:17][CH:18]=[C:19]([C:20]3[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=3)[C:11]=2[S:10][CH2:9]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86629176HCID 86629176, compound

Product 1

HCID 67242480HCID 67242480, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

8 mL of a solution of hydrogen chloride in dioxane (4 M) are placed in a 50 mL round-bottomed flask containing 410 mg of 40 (1.107 mmol). The mixture is stirred for 4 hours at room temperature under argon. A white precipitate forms, which is filtered off by suction and washed with 3 mL of dioxane and then 5 mL of isopropyl ether. 260 mg of amine 41 (white solid) are thus obtained in the form of the hydrochloride.

Workup

  1. filtrationA white precipitate forms, which is filtered off by suction
  2. washwashed with 3 mL of dioxane

Sources & evidence

ORD record
ord-1b5e732b1bc04b5a8597dc8e70968006
Source dataset
uspto-grants-2011_06
Patent number
US07960373B2

Reaction notes

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