Hydrochloric Acid → HCID 67241054, compound

HRID 2421864Notes

Reaction equation

HRID 2421864 reaction equation
[ClH:1].CC(C)(C)C(O[NH:7][C@@H:8]1[C:14](=[O:15])[NH:13][C:12]2[CH:16]=[CH:17][CH:18]=[C:19]([C:20]3[CH:21]=[C:22]([CH:25]=[CH:26][CH:27]=3)[C:23]#[N:24])[C:11]=2[S:10][CH2:9]1)=O>O1CCOCC1>[ClH:1].[NH2:7][C@@H:8]1[C:14](=[O:15])[NH:13][C:12]2[CH:16]=[CH:17][CH:18]=[C:19]([C:20]3[CH:21]=[C:22]([CH:25]=[CH:26][CH:27]=3)[C:23]#[N:24])[C:11]=2[S:10][CH2:9]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86629179HCID 86629179, compound

Product 1

HCID 67241054HCID 67241054, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

2.6 mL of a solution of hydrogen chloride in dioxane (4 M) are added to a 25 mL round-bottomed flask containing 139 mg of 45 (0.352 mmol). The mixture is stirred for 4 hours at room temperature under argon. A white precipitate forms, which is filtered off by suction and washed with 3 mL of dioxane and then 5 mL of isopropyl ether. 72 mg of amine 46 (white solid) are thus obtained in the form of the hydrochloride.

Workup

  1. filtrationA white precipitate forms, which is filtered off by suction
  2. washwashed with 3 mL of dioxane

Sources & evidence

ORD record
ord-c0949d2846924186b14c071fcf77d56e
Source dataset
uspto-grants-2011_06
Patent number
US07960373B2

Reaction notes

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