Hydrochloric Acid → HCID 67243260, compound

HRID 2421867Notes

Reaction equation

HRID 2421867 reaction equation
[ClH:1].CC(C)(C)C(O[NH:7][C@@H:8]1[C:14](=[O:15])[NH:13][C:12]2[C:16]([F:20])=[CH:17][CH:18]=[CH:19][C:11]=2[S:10][CH2:9]1)=O>O1CCOCC1>[ClH:1].[NH2:7][C@@H:8]1[C:14](=[O:15])[NH:13][C:12]2[C:16]([F:20])=[CH:17][CH:18]=[CH:19][C:11]=2[S:10][CH2:9]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86629182HCID 86629182, compound

Product 1

HCID 67243260HCID 67243260, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

1.6 mL of a solution of hydrogen chloride in dioxane (4 M) are added to a 25 mL round-bottomed flask containing 68.4 mg of 50 (0.219 mmol). The mixture is stirred for 4 hours at room temperature under argon. After concentrating the reaction medium to dryness, 51 mg of amine 51 (yellow solid) are thus obtained in the form of the hydrochloride.

Workup

  1. concentrationAfter concentrating the reaction medium to dryness, 51 mg of amine 51 (yellow solid)

Sources & evidence

ORD record
ord-5bfa3a66067343e0b192981d52e132c1
Source dataset
uspto-grants-2011_06
Patent number
US07960373B2

Reaction notes

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