Hydrochloric Acid → HCID 67240807, compound

HRID 2421871Notes

Reaction equation

HRID 2421871 reaction equation
[ClH:1].CC(C)(C)C(O[NH:7][C@@H:8]1[C:14](=[O:15])[NH:13][C:12]2[C:16]([O:20][CH3:21])=[CH:17][CH:18]=[CH:19][C:11]=2[S:10][CH2:9]1)=O>O1CCOCC1>[ClH:1].[NH2:7][C@@H:8]1[C:14](=[O:15])[NH:13][C:12]2[C:16]([O:20][CH3:21])=[CH:17][CH:18]=[CH:19][C:11]=2[S:10][CH2:9]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86629185HCID 86629185, compound

Product 1

HCID 67240807HCID 67240807, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

10.4 mL of a solution of hydrogen chloride in dioxane (4 M) are placed in a 100 mL round-bottomed flask containing 450 mg of 55 (1.387 mmol). The mixture is stirred for 3 hours at room temperature under argon. A white precipitate forms, which is filtered off by suction and washed with 3 mL of dioxane and then 5 mL of isopropyl ether. 259 mg of amine 56 (cream-coloured solid) are thus obtained in the form of the hydrochloride.

Workup

  1. filtrationA white precipitate forms, which is filtered off by suction
  2. washwashed with 3 mL of dioxane

Sources & evidence

ORD record
ord-b6a7b052d3d04aa6a6ccea2a726bc156
Source dataset
uspto-grants-2011_06
Patent number
US07960373B2

Reaction notes

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