Hydrochloric Acid → HCID 67242126, compound

HRID 2421875Notes

Reaction equation

HRID 2421875 reaction equation
[ClH:1].CC(C)(C)C(O[NH:7][C@@H:8]1[C:14](=[O:15])[NH:13][C:12]2[C:16]([O:20][C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)=[CH:17][CH:18]=[CH:19][C:11]=2[S:10][CH2:9]1)=O>O1CCOCC1>[ClH:1].[NH2:7][C@@H:8]1[C:14](=[O:15])[NH:13][C:12]2[C:16]([O:20][C:21]3[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=3)=[CH:17][CH:18]=[CH:19][C:11]=2[S:10][CH2:9]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86629188HCID 86629188, compound

Product 1

HCID 67242126HCID 67242126, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

3.65 mL of a solution of hydrogen chloride in dioxane (4 M) are placed in a 100 mL round-bottomed flask containing 188 mg of 60 (0.487 mmol). The reaction medium is concentrated to dryness and the residue is taken up in 10 mL of isopropyl ether. After filtering, 100 mg of amine 61 (white solid) are obtained in the form of the hydrochloride.

Workup

  1. concentrationThe reaction medium is concentrated to dryness
  2. filtrationAfter filtering

Sources & evidence

ORD record
ord-fea3a912650f4fd99b5c5ffe2d9a32e2
Source dataset
uspto-grants-2011_06
Patent number
US07960373B2

Reaction notes

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