1-(4-Fluorophenyl)piperazine → HCID 58834858, compound

HRID 2421926Notes

Reaction equation

HRID 2421926 reaction equation
C1(P(=[N:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=2/[CH:27]=[CH:28]/[C:29]([O:31][CH3:32])=[O:30])(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.[F:33][C:34]1[CH:39]=[CH:38][C:37]([N:40]=[C:41]=O)=[CH:36][C:35]=1[C:43]([F:46])([F:45])[F:44].[F:47][C:48]1[CH:53]=[CH:52][C:51]([N:54]2[CH2:59][CH2:58][NH:57][CH2:56][CH2:55]2)=[CH:50][CH:49]=1>>[F:47][C:48]1[CH:49]=[CH:50][C:51]([N:54]2[CH2:59][CH2:58][N:57]([C:41]3[N:40]([C:37]4[CH:36]=[C:35]([C:43]([F:46])([F:45])[F:44])[C:34]([F:33])=[CH:39][CH:38]=4)[CH:27]([CH2:28][C:29]([O:31][CH3:32])=[O:30])[C:22]4[C:21](=[CH:26][CH:25]=[CH:24][CH:23]=4)[N:20]=3)[CH2:56][CH2:55]2)=[CH:52][CH:53]=1

Participants

4

Reactant 3

HCID 752601-(4-Fluorophenyl)piperazineHCID 27333834-Fluoro-3-(trifluoromethyl)phenyl isocyanateHCID 11826263HCID 11826263, compound

Product 1

HCID 58834858HCID 58834858, compound

Procedure

Starting with 150 mg (0.34 mmol) of the iminophosphorane from Example 3A, 74 mg (0.34 mmol) of 4-fluoro-3-(trifluoromethyl)phenyl isocyanate and 61 mg (0.34 mmol) of N-(4-fluorophenyl)piperazine, the general procedure [E] and chromatographic purification (method 2) give 111 mg (54% of theory) of product.

Workup

  1. customthe general procedure [E] and chromatographic purification (method 2)
  2. customgive 111 mg (54% of theory) of product

Sources & evidence

ORD record
ord-2430be76b1f14003935d7f8e8f232c94
Source dataset
uspto-grants-2011_06
Patent number
US07960387B2

Reaction notes

Loading…