反应详情

To a solution of methyl 4-[(4-aminophenyl) methoxy]benzenepropanoate (0.13 g, 0.44 mmol) and triethylamine (0.50 mL) in tetrahydrofuran (9 mL) was added benzoyl chloride (74 mg, 0.53 mmol), and the mixture was stirred at room temperature for 2 hrs. Water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The extract was washed with water, dried and concentrated. The residue was purified by silica gel column chromatography (hexane/ethyl acetate=18:1) to give the title compound (0.23 g, quantitative). oil.

1. extractionthe mixture was extracted with ethyl acetate
2. washThe extract was washed with water
3. customdried
4. concentrationconcentrated
5. customThe residue was purified by silica gel column chromatography (hexane/ethyl acetate=18:1)