反应详情

温度

100 °C

5.0 g (31.7 mmol) 6-chloronicotinic acid and 30.9 ml (31.8 g, 634.7 mmol) hydrazine hydrate are initially introduced into 10 ml ethanol and the mixture is stirred at the boiling point at a bath temperature of 100° C. for 16 h. The solvent and excess hydrazine hydrate are distilled off on a rotary evaporator, the residue is taken up in water, 1.8 g (31.7 mmol) potassium hydroxide are then added and the mixture is stirred for 15 min. The solvent is removed completely on a rotary evaporator, the residue is dried in vacuo and 7.5 g of crude product, which is reacted further as such, are obtained.

1. distillationThe solvent and excess hydrazine hydrate are distilled off on a rotary evaporator
2. stirringthe mixture is stirred for 15 min
3. customThe solvent is removed completely on a rotary evaporator
4. dry with materialthe residue is dried in vacuo and 7.5 g of crude product, which
5. customis reacted further as such,
6. customare obtained