反应详情

6 M hydrochloric acid (7 ml) was added to a solution of (8-benzyl-1,4-dioxaspiro[4,5]dec-8-yl)(4-methoxybenzyl)amine (1.2 g, 3.3 mmol) in acetone (17 ml). The reaction solution was stirred for 20 h at room temperature, then made alkaline (pH˜9) with 25% potassium carbonate solution and extracted with diethyl ether (3×20 ml). The combined organic phases were dried with sodium sulfate and concentrated to approx. 10 ml under vacuum. The precipitated deposit was filtered off and dried under vacuum. Yield: 790 mg (74%), white solid. Melting point: 122-124° C.

1. extractionextracted with diethyl ether (3×20 ml)
2. dry with materialThe combined organic phases were dried with sodium sulfate
3. concentrationconcentrated to approx. 10 ml under vacuum
4. filtrationThe precipitated deposit was filtered off
5. customdried under vacuum