Methylamine → 2-[4-(1-Cyclopentyl-4-piperidinyloxy)phenyl]-3-methylpyrido[2,3-d]-pyrimidin-4(3H)-one

HRID 2422593Notes

Reaction equation

HRID 2422593 reaction equation
[NH2:1][C:2]1[N:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=O.[CH3:11][NH2:12].[CH:13]1([N:18]2[CH2:23][CH2:22][CH:21]([O:24][C:25]3[CH:32]=[CH:31][C:28]([CH:29]=O)=[CH:27][CH:26]=3)[CH2:20][CH2:19]2)[CH2:17][CH2:16][CH2:15][CH2:14]1>>[CH:13]1([N:18]2[CH2:23][CH2:22][CH:21]([O:24][C:25]3[CH:32]=[CH:31][C:28]([C:29]4[N:12]([CH3:11])[C:4](=[O:6])[C:3]5[CH:7]=[CH:8][CH:9]=[N:10][C:2]=5[N:1]=4)=[CH:27][CH:26]=3)[CH2:20][CH2:19]2)[CH2:17][CH2:16][CH2:15][CH2:14]1

Participants

4

Reactant 3

HCID 6329MethylamineHCID 729302-Aminonicotinic acidHCID 866244604-[(1-Cyclopentyl-4-piperidinyl)oxy]benzaldehyde

Product 1

HCID 115315302-[4-(1-Cyclopentyl-4-piperidinyloxy)phenyl]-3-methylpyrido[2,3-d]-pyrimidin-4(3H)-one

Procedure

The entitled compound was obtained according to the method of Example 15 but starting from 2-aminonicotinic acid, methylamine and 4-[(1-cyclopentyl-4-piperidinyl)oxy]benzaldehyde. The obtained compound was recrystallized from diethyl ether to give a pale yellow acicular crystal (m.p. 175.0-177.2° C.).

Workup

  1. customThe entitled compound was obtained
  2. customThe obtained compound was recrystallized from diethyl ether

Sources & evidence

ORD record
ord-a1d5c9fda8ec46bdbbb4ec086fa42c81
Source dataset
uspto-grants-2011_06
Patent number
US07960394B2

Reaction notes

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