Methylamine → 6-Chloro-2-{4-[(1-cyclopentylpiperidin-4-yl)oxy]phenyl}-3-methylpyrido[3,4-d]pyrimidin-4(3H)-one

HRID 2422600Notes

Reaction equation

HRID 2422600 reaction equation
[NH2:1][C:2]1[C:7]([C:8]([OH:10])=O)=[CH:6][C:5]([Cl:11])=[N:4][CH:3]=1.[CH3:12][NH2:13].[CH:14]1([N:19]2[CH2:24][CH2:23][CH:22]([O:25][C:26]3[CH:33]=[CH:32][C:29]([CH:30]=O)=[CH:28][CH:27]=3)[CH2:21][CH2:20]2)[CH2:18][CH2:17][CH2:16][CH2:15]1>>[Cl:11][C:5]1[N:4]=[CH:3][C:2]2[N:1]=[C:30]([C:29]3[CH:32]=[CH:33][C:26]([O:25][CH:22]4[CH2:23][CH2:24][N:19]([CH:14]5[CH2:18][CH2:17][CH2:16][CH2:15]5)[CH2:20][CH2:21]4)=[CH:27][CH:28]=3)[N:13]([CH3:12])[C:8](=[O:10])[C:7]=2[CH:6]=1

Participants

4

Reactant 3

HCID 6329MethylamineHCID 227367915-Amino-2-chloro-isonicotinic acidHCID 866244604-[(1-Cyclopentyl-4-piperidinyl)oxy]benzaldehyde

Product 1

HCID 117048196-Chloro-2-{4-[(1-cyclopentylpiperidin-4-yl)oxy]phenyl}-3-methylpyrido[3,4-d]pyrimidin-4(3H)-one

Procedure

The entitled compound was obtained according to the method of Example 15 but starting from 5-amino-2-chloroisonicotinic acid, methylamine and 4-[(1-cyclopentyl-4-piperidinyl)oxy]benzaldehyde.

Workup

  1. customThe entitled compound was obtained

Sources & evidence

ORD record
ord-ff678b8d2f144670a8d7826251978720
Source dataset
uspto-grants-2011_06
Patent number
US07960394B2

Reaction notes

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