Methylamine → HCID 11502638, compound

HRID 2422657Notes

Reaction equation

[NH2:1][C:2]1[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[CH:7][C:3]=1[C:4]([OH:6])=O.[CH3:13][NH2:14].[CH3:15][O:16][C:17]1[CH:24]=[CH:23][C:20]([CH:21]=O)=[CH:19][CH:18]=1.OC1[CH2:31][CH2:30][N:29](C(OC(C)(C)C)=O)[CH2:28][CH2:27]1.[C:39]1(=O)[CH2:42][CH2:41][CH2:40]1>>[CH3:12][O:11][C:8]1[CH:7]=[C:3]2[C:2](=[CH:10][CH:9]=1)[N:1]=[C:21]([C:20]1[CH:23]=[CH:24][C:17]([O:16][CH:15]3[CH2:31][CH2:30][N:29]([CH:39]4[CH2:42][CH2:41][CH2:40]4)[CH2:28][CH2:27]3)=[CH:18][CH:19]=1)[N:14]([CH3:13])[C:4]2=[O:6]

Participants

Reactant 5

HCID 6329Methylamine

HCID 14496Cyclobutanone

HCID 312444-Methoxybenzaldehyde

HCID 2779305-Methoxyanthranilic acid

HCID 643502Tert-butyl 4-hydroxypiperidine-1-carboxylate

Product 1

HCID 11502638HCID 11502638, compound

Procedure

The entitled compound was obtained according to the method of Example 85 but using 2-amino-5-methoxybenzoic acid, methylamine, 4-methoxybenzaldehyde, tert-butyl 4-hydroxytetrahydro-1(2H)-pyridinecarboxylate, and cyclobutanone.

Workup

customThe entitled compound was obtained

Sources & evidence

ORD record: ord-9fbca0d45a5941b685680490aed14e71
Source dataset: uspto-grants-2011_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07960394B2

Reaction notes

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