Methylamine → HCID 11654348, compound

HRID 2422659Notes

Reaction equation

HRID 2422659 reaction equation
[NH2:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([O:11][CH3:12])[C:3]=1[C:4]([OH:6])=O.[CH3:13][NH2:14].[CH3:15][O:16][C:17]1[CH:24]=[CH:23][C:20]([CH:21]=O)=[CH:19][CH:18]=1.OC1[CH2:31][CH2:30][N:29](C(OC(C)(C)C)=O)[CH2:28][CH2:27]1.C(O[C:42]1(O[Si](C)(C)C)[CH2:44][CH2:43]1)C>>[CH3:12][O:11][C:7]1[CH:8]=[CH:9][CH:10]=[C:2]2[C:3]=1[C:4](=[O:6])[N:14]([CH3:13])[C:21]([C:20]1[CH:23]=[CH:24][C:17]([O:16][CH:15]3[CH2:31][CH2:30][N:29]([CH:42]4[CH2:43][CH2:44]4)[CH2:28][CH2:27]3)=[CH:18][CH:19]=1)=[N:1]2

Participants

6

Reactant 5

HCID 6329MethylamineHCID 312444-MethoxybenzaldehydeHCID 643502Tert-butyl 4-hydroxypiperidine-1-carboxylateHCID 2734686(1-Ethoxycyclopropoxy)trimethylsilaneHCID 27353572-Amino-6-methoxybenzoic Acid

Product 1

HCID 11654348HCID 11654348, compound

Procedure

The entitled compound was obtained according to the method of Example 85 but using 2-amino-6-methoxybenzoic acid, methylamine, 4-methoxybenzaldehyde, tert-butyl 4-hydroxytetrahydro-1(2H)-pyridinecarboxylate, and [(1-ethoxycyclopropyl)oxy](trimethyl)silane.

Workup

  1. customThe entitled compound was obtained

Sources & evidence

ORD record
ord-cc14296097b84425924ec2e88afd8f48
Source dataset
uspto-grants-2011_06
Patent number
US07960394B2

Reaction notes

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