4-Hydroxybenzaldehyde → HCID 11662780, compound

HRID 2422661Notes

Reaction equation

HRID 2422661 reaction equation
[NH2:1][C:2]1[C:3]([C:9]([OH:11])=O)=[N:4][CH:5]=[C:6]([Br:8])[CH:7]=1.[CH3:12][NH2:13].[OH:14][C:15]1[CH:22]=[CH:21][C:18]([CH:19]=O)=[CH:17][CH:16]=1.O[CH:24]1[CH2:29][CH2:28][N:27]([C:30](OC(C)(C)C)=O)[CH2:26][CH2:25]1.[C:37]1(=O)[CH2:40]C[CH2:38]1>>[Br:8][C:6]1[CH:5]=[N:4][C:3]2[C:9](=[O:11])[N:13]([CH3:12])[C:19]([C:18]3[CH:21]=[CH:22][C:15]([O:14][CH:24]4[CH2:25][CH2:26][N:27]([CH:30]5[CH2:40][CH2:37][CH2:38]5)[CH2:28][CH2:29]4)=[CH:16][CH:17]=3)=[N:1][C:2]=2[CH:7]=1

Participants

6

Reactant 5

HCID 1264-HydroxybenzaldehydeHCID 6329MethylamineHCID 14496CyclobutanoneHCID 643502Tert-butyl 4-hydroxypiperidine-1-carboxylateHCID 497615813-Amino-5-bromopyridine-2-carboxylic acid

Product 1

HCID 11662780HCID 11662780, compound

Procedure

The entitled compound was obtained according to the method of Example 85 but using 3-amino-5-bromopyridine-2-carboxylic acid, methylamine, 4-hydroxybenzaldehyde, tert-butyl 4-hydroxytetrahydro-1(2H)-pyridinecarboxylate, and cyclobutanone.

Workup

  1. customThe entitled compound was obtained

Sources & evidence

ORD record
ord-e0abcb0337d346c2bfa6e6e7a02bb02e
Source dataset
uspto-grants-2011_06
Patent number
US07960394B2

Reaction notes

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