Dimethylformamide → HCID 25053961, compound

HRID 2423158Notes

Reaction equation

HRID 2423158 reaction equation
[CH2:1]1[C:7]2=[C:8]3[C:12](=[CH:13][CH:14]=[C:6]2[O:5][CH2:4][CH2:3][N:2]1C(OC(C)(C)C)=O)[NH:11][CH:10]=[CH:9]3.[H-].[Na+].CN(C=O)C.[F:29][C:30]1[CH:31]=[CH:32][C:33]([CH3:40])=[C:34]([S:36](Cl)(=[O:38])=[O:37])[CH:35]=1>N.CO>[F:29][C:30]1[CH:31]=[CH:32][C:33]([CH3:40])=[C:34]([S:36]([N:11]2[C:12]3[C:8](=[C:7]4[CH2:1][NH:2][CH2:3][CH2:4][O:5][C:6]4=[CH:14][CH:13]=3)[CH:9]=[CH:10]2)(=[O:38])=[O:37])[CH:35]=1

Participants

7

Reactant 4

HCID 6228DimethylformamideHCID 24758Sodium hydrideHCID 1362865-Fluoro-2-methylbenzenesulphonyl chlorideHCID 67242130HCID 67242130, compound2×

Product 1

HCID 25053961HCID 25053961, compoundYield 15%

Reagents, catalysts & solvents 2

HCID 222AmmoniaSolventHCID 887MethanolSolvent3×

Procedure

tert-Butyl 1,3,4,8-tetrahydro-2H-[1,4]oxazepino[6,7-e]indole-2-carboxylate (Intermediate 18, 14 mg, 0.050 mmol), NaH (60% in mineral oil, 6.4 mg, 0.10 mmol) and dry DMF (0.2 mL) were shaken at room temperature for 10 minutes. 5-Fluoro-2-methylbenzenesulfonyl chloride (21 mg, 0.10 mmol, in 0.15 mL of dry DMF) was added to the solution. The reaction mixture was shaken at room temperature for another 20 minutes and a mixture of MeOH/1 M HCl (3:1, 1 mL) was added. The reaction mixture was stirred overnight and evaporated. The residue was dissolved in 1 M NH3 in MeOH (1 mL, 1 mmol) and MeOH (1 mL). The crude product was purified by preparative HPLC (XTerra C18, 50 mM NH4HCO3 pH 10-CH3CN) to give the title compound as an off-white solid (2.7 mg). MS m/z 361 [M+H]+.

Workup

  1. additionwas added
  2. stirringThe reaction mixture was stirred overnight
  3. customevaporated
  4. customThe crude product was purified by preparative HPLC (XTerra C18, 50 mM NH4HCO3 pH 10-CH3CN)

Sources & evidence

ORD record
ord-4735580d496e4ce794734e569143fde4
Source dataset
uspto-grants-2011_06
Patent number
US07960374B2

Reaction notes

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