HCID 59864897, compound → HCID 59864864, compound

HRID 2423296Notes

Reaction equation

HRID 2423296 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([O:8][C:9]2[CH:19]=[CH:18][C:12]3[N:13]=[C:14]([NH:16][CH3:17])[S:15][C:11]=3[C:10]=2[N+:20]([O-])=O)[C:5]([O:23][CH3:24])=[CH:4][C:3]=1[CH2:25][C:26]([O:28][CH3:29])=[O:27]>C(OCC)(=O)C.CO.[Pd]>[NH2:20][C:10]1[C:11]2[S:15][C:14]([NH:16][CH3:17])=[N:13][C:12]=2[CH:18]=[CH:19][C:9]=1[O:8][C:6]1[C:5]([O:23][CH3:24])=[CH:4][C:3]([CH2:25][C:26]([O:28][CH3:29])=[O:27])=[C:2]([Cl:1])[CH:7]=1

Participants

5

Reactant 1

HCID 59864897HCID 59864897, compound

Product 1

HCID 59864864HCID 59864864, compound

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 887MethanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

Compound 19.3 (230 mg, 0.53 mmol) was dissolved in mixture of ethyl acetate (3 mL) and methanol (1 mL). 10% Pd/C (56 mg, 0.053 mmol) was added and the reaction mixture was stirred for 1.5 h under H2 at room temperature. The reaction mixture was filtered, the residue concentrated under reduced pressure to afford 19.4.

Workup

  1. filtrationThe reaction mixture was filtered
  2. concentrationthe residue concentrated under reduced pressure

Sources & evidence

ORD record
ord-453cb26558614bbeb124dd9ed37f28c9
Source dataset
uspto-grants-2011_06
Patent number
US07960567B2

Reaction notes

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