Dichloromethane → HCID 67245786, compound

HRID 2423339Notes

Reaction equation

HRID 2423339 reaction equation
C(OC(=O)[NH:7][CH2:8][C:9]1[CH:14]=[C:13](C)[C:12]([NH:16][S:17]([CH3:20])(=[O:19])=[O:18])=[C:11]([I:21])[CH:10]=1)(C)(C)C.C(Cl)[Cl:24]>C(O)(C(F)(F)F)=O>[NH2:7][CH2:8][C:9]1[CH:10]=[C:11]([I:21])[C:12]([NH:16][S:17]([CH3:20])(=[O:19])=[O:18])=[C:13]([Cl:24])[CH:14]=1

Participants

4

Reactant 2

HCID 6344DichloromethaneHCID 67243224HCID 67243224, compound

Product 1

HCID 67245786HCID 67245786, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidCatalyst

Procedure

(3-Iodo-4-methanesulfonylamino-5-methylbenzyl)carbamic acid t-butyl ester (122.0 mg, 0.27 mmol) and CF3COOH (5˜6 drops) were added into methylene chloride. The mixture was stirred for 12 hrs. The mixture was concentrated in vacuo to yield brownish syrup (142.2 mg, 100%).

Workup

  1. concentrationThe mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-5d3dd03467844084a740d5c0e54a7c29
Source dataset
uspto-grants-2011_06
Patent number
US07960584B2

Reaction notes

Loading…