4-Piperidinol, 1-methyl- → HCID 23087228, compound

HRID 2423573Notes

Reaction equation

HRID 2423573 reaction equation
[OH:1]C1CCN(C)CC1.FC1C=C(C=CC=1F)C#N.[F:19][C:20]1[CH:21]=[C:22]([CH:25]=[CH:26][C:27]=1[O:28][CH:29]1[CH2:34][CH2:33][N:32]([CH3:35])[CH2:31][CH2:30]1)[C:23]#N>>[F:19][C:20]1[CH:21]=[C:22]([CH:25]=[CH:26][C:27]=1[O:28][CH:29]1[CH2:34][CH2:33][N:32]([CH3:35])[CH2:31][CH2:30]1)[CH:23]=[O:1]

Participants

4

Reactant 3

HCID 660484-Piperidinol, 1-methyl-HCID 5872033,4-DifluorobenzonitrileHCID 230874123-Fluoro-4-(1-methylpiperidin-4-yloxy)benzonitrile

Product 1

HCID 23087228HCID 23087228, compound

Procedure

Synthesized from 4-hydroxy-1-methylpiperidine and 3,4-difluorobenzonitrile according to an analogous synthetic method to Preparation Example 15, 3-fluoro-4-(1-methylpiperidin-4-yloxy)benzonitrile (1.1 g) was used according to an analogous synthetic method to Preparation Example 16 to provide the title compound (1.1 g).

Workup

  1. customwas used according to an analogous synthetic method to Preparation Example 16

Sources & evidence

ORD record
ord-7da41b010ebd47aab4379e8fc531c776
Source dataset
uspto-grants-2011_06
Patent number
US07960412B2

Reaction notes

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