Trifluoroacetic acid → HCID 25206093, compound

HRID 2424406Notes

Reaction equation

HRID 2424406 reaction equation
[CH3:1][CH:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][C:8]=2[N:12]2[CH2:17][CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14][CH2:13]2)[N:3]1[S:25]([C:28]1[CH:37]=[CH:36][C:35]2[C:30](=[CH:31][CH:32]=[CH:33][CH:34]=2)[CH:29]=1)(=[O:27])=[O:26].[C:38]([OH:44])([C:40]([F:43])([F:42])[F:41])=[O:39]>C(Cl)Cl>[F:41][C:40]([F:43])([F:42])[C:38]([OH:44])=[O:39].[CH3:1][CH:2]1[CH2:11][CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][C:8]=2[N:12]2[CH2:13][CH2:14][NH:15][CH2:16][CH2:17]2)[N:3]1[S:25]([C:28]1[CH:37]=[CH:36][C:35]2[C:30](=[CH:31][CH:32]=[CH:33][CH:34]=2)[CH:29]=1)(=[O:27])=[O:26]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86626635HCID 86626635, compound

Product 1

HCID 25206093HCID 25206093, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The compound prepared in example 8 (260 mg, 0.62 mmol) was dissolved in a mixture of 1 mL TFA and 4 mL CH2Cl2 and stirred for 30 min. The solvent was evaporated and the crude product was purified by a short silica gel column (using CH2Cl2-MeOH 98:2 as eluent). Yield: 180 mg (85.6%) Rf=0.38 (CH2Cl2-MeOH 9:1).

Workup

  1. customThe solvent was evaporated
  2. customthe crude product was purified by a short silica gel column (using CH2Cl2-MeOH 98:2 as eluent)

Sources & evidence

ORD record
ord-74a077dc059e4cad86cc48aeec788ef5
Source dataset
uspto-grants-2011_06
Patent number
US07964603B2

Reaction notes

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