Dimethyl Sulfoxide → HCID 66902439, compound

Temperature

0 °C

To a solution of dimethylsulfoxide (33.4 mL, 471 mmol) in 194 mL of methylene chloride at −70° C. is slowly added a solution of trifluoracetic anhydride (33.2 mL, 235 mmol) in 73 mL of methylene chloride over 30 minutes (temperature maintained below −66° C.). After stirring for 20 min, a solution of ethyl (4S,6S)-4-hydroxy-2-thiabicyclo[3.1.0]hexane-6-carboxylate (34.1 g, 181 mmol) in 194 mL of methylene chloride is added over 60 minutes such that the temperature is maintained below 40° C. After stirring for 1 hour, the reaction is treated with triethylamine (75.7 mL, 543 mmol) over 35 minutes such that the temperature remains below −50° C. The reaction is allowed to stir an additional 1 hour, at which time the cooling bath is removed and 400 mL of 2 N hydrochloric acid is added. Upon warming to 0° C., the layers are separated and the organic layer is washed with 2N hydrochloric acid (1×300 mL), 1N aqueous sodium bicarbonate (1×670 mL), and water (1×300 mL) followed by drying over sodium sulfate, filtering, and concentrating in vacuo to a red oil which solidifies upon standing. The crude product is applied to a pad of silica gel (2 g per 1 g of starting alcohol packed with methylene chloride) and eluted with methylene chloride (200-300 mL). All fractions containing product are collected and concentrated to provide the title compound as an orange/brown solid. Typical corrected yields are in the 85-90% range.

1. temperature(temperature maintained below −66° C.)
2. temperatureis maintained below 40° C
3. stirringAfter stirring for 1 hour
4. customremains below −50° C
5. stirringto stir an additional 1 hour, at which time the cooling bath
6. customis removed
7. addition400 mL of 2 N hydrochloric acid is added
8. customthe layers are separated
9. washthe organic layer is washed with 2N hydrochloric acid (1×300 mL), 1N aqueous sodium bicarbonate (1×670 mL), and water (1×300 mL)
10. dry with materialby drying over sodium sulfate
11. filtrationfiltering
12. concentrationconcentrating in vacuo to a red oil which
13. washeluted with methylene chloride (200-300 mL)
14. additionAll fractions containing product
15. customare collected
16. concentrationconcentrated

ORD record

ord-578929e287f74d1d9814a7abda51967c

Source dataset

uspto-grants-2011_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07964632B2