Hydrochloric Acid → HCID 67245521, compound

HRID 2425116Notes

Reaction equation

HRID 2425116 reaction equation
Cl.[Cl:2][C:3]1[CH:13]=[C:12]([O:14]C(=O)C)[C:11]([O:18][CH3:19])=[CH:10][C:4]=1[CH2:5][NH:6]C(=O)C>C(O)C>[ClH:2].[Cl:2][C:3]1[CH:13]=[C:12]([OH:14])[C:11]([O:18][CH3:19])=[CH:10][C:4]=1[CH2:5][NH2:6]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67245595HCID 67245595, compound

Product 1

HCID 67245521HCID 67245521, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

37% hydrochloric acid (2.5 ml) was added to a solution of 2-chloro-4-acetyloxy-5-methoxy-N-acetyl-benzylamine 2b (0.45 g, 1.66 mmol) in abs. ethanol (15 ml) and the mixture was refluxed for 12 hours. The reaction was cooled and the solvent was evaporated under reduced pressure. The residue was recrystallized from dry acetone to afford the title compound as white crystals in quantitative yield.

Workup

  1. temperatureThe reaction was cooled
  2. customthe solvent was evaporated under reduced pressure
  3. customThe residue was recrystallized from dry acetone

Sources & evidence

ORD record
ord-9ab8459f1bf94569beca359e117ff8f5
Source dataset
uspto-grants-2011_06
Patent number
US07964642B2

Reaction notes

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