Water → 4'-Bromobiphenyl-4-sulfonic acid (4-isopropylamino-butyl) amide

HRID 2425171Notes

Reaction equation

HRID 2425171 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][NH:6][S:7]([C:10]1[CH:15]=[CH:14][C:13]([C:16]2[CH:21]=[CH:20][C:19]([Br:22])=[CH:18][CH:17]=2)=[CH:12][CH:11]=1)(=[O:9])=[O:8].C([O-])([O-])=O.[K+].[K+].I[CH:30]([CH3:32])[CH3:31].O>CN(C=O)C>[CH:30]([NH:1][CH2:2][CH2:3][CH2:4][CH2:5][NH:6][S:7]([C:10]1[CH:15]=[CH:14][C:13]([C:16]2[CH:17]=[CH:18][C:19]([Br:22])=[CH:20][CH:21]=2)=[CH:12][CH:11]=1)(=[O:9])=[O:8])([CH3:32])[CH3:31]

Participants

6

Reactant 4

HCID 962WaterHCID 6362Isopropyl iodideHCID 11430Potassium CarbonateHCID 116966484'-Bromobiphenyl-4-sulfonic acid (4-amino-butyl) amide

Product 1

HCID 115027664'-Bromobiphenyl-4-sulfonic acid (4-isopropylamino-butyl) amide

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

4′-Bromobiphenyl-4-sulfonic acid (4-amino-butyl) amide (0.6 g) was dissolved in DMF (30 mL). K2CO3 (1 g) was added followed by 2-iodo-propane (0.3 mL). The mixture was stirred for 3 hrs, poured into water, extracted with ether and dried. Addition of petrol and evaporation caused the title compound to precipitate as a white solid.

Workup

  1. extractionextracted with ether
  2. customdried
  3. additionAddition of petrol and evaporation
  4. customto precipitate as a white solid

Sources & evidence

ORD record
ord-ab6479150f1d4b4083e86a77673be9db
Source dataset
uspto-grants-2011_06
Patent number
US07964643B2

Reaction notes

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